Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs

Hadighi, R. and Boucher, P. and Khamesipour, A. and Meamar, A.R. and Roy, G. and Ouellette, M. and Mohebali, M. (2007) Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs. Parasitology Research, 101 (5). pp. 1319-1322.

[img] Text
Leishmania.pdf

Download (62kB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Cutaneous leishmaniasis (CL) is a major health problem in endemic areas of Iran. The pentavalent antimony (SbV) based drug Glucantime is the first line of treatment for CL in Iran, but recently SbV-resistant Leishmania tropica isolates derived from unresponsive patients were reported. We show in this study that these resistant parasites are cross-resistant to the other SbV-containing drug Pentostam and at least for one isolate also to amphotericin B. However, these resistant isolates were shown to be sensitive to miltefosine and paromomycin. The latter two drugs could thus be useful alternatives for the treatment of leishmaniasis in Iran even for SbV-resistant isolates. © 2007 Springer-Verlag.

Item Type: Article
Additional Information: cited By 58
Uncontrolled Keywords: amphotericin B; meglumine antimonate; miltefosine; paromomycin; stibogluconate sodium, article; controlled study; cross resistance; drug resistance; human; human cell; Iran; Leishmania tropica; nonhuman; parasite isolation; priority journal; skin leishmaniasis; visceral leishmaniasis, Amphotericin B; Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Drug Resistance; Humans; Iran; Leishmania tropica; Leishmaniasis, Cutaneous; Meglumine; Organometallic Compounds; Parasitic Sensitivity Tests; Paromomycin; Phosphorylcholine, Leishmania tropica
Subjects: WR Dermatology
QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 08:54
Last Modified: 26 Feb 2019 08:54
URI: http://eprints.iums.ac.ir/id/eprint/10676

Actions (login required)

View Item View Item