The mitochondrial K-ATP channel opener, diazoxide, protects brain against ischemia-reperfusion injury in the rat

Mehdizadeh, M. and Soleimani, M. and Katebi, M. and Pazouki, H.R. and Joghataei, M.T. and Latifi, N.A. and Bakhshayesh, M. (2007) The mitochondrial K-ATP channel opener, diazoxide, protects brain against ischemia-reperfusion injury in the rat. Pakistan Journal of Medical Sciences, 23 (5). pp. 741-746.

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Abstract

Objective: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. The objective of this research was to study effects of the mitochondrial K-ATP (MAK) channel regulators on neuronal cell population and neurological function after ischemia reperfusion in the rat. Methodology: Rats were temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without MAK channel regulators. Results: The normal cell count of neuronal population significantly increased in the K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with the control group. Cell count and neurological function scores were dose dependent to MAK channel regulators in vivo. Conclusions: Our results showed that diazoxide treatment leads to better preservation of cortical neurons in rat.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: diazoxide; potassium channel stimulating agent, animal cell; animal experiment; animal model; article; brain injury; brain ischemia; brain nerve cell; brain protection; carotid artery obstruction; cell count; cell population; controlled study; dose response; drug effect; in vivo study; male; mitochondrion; nerve function; nonhuman; rat; reperfusion injury; scoring system; vertebral artery stenosis
Subjects: QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 08:54
Last Modified: 26 Feb 2019 08:54
URI: http://eprints.iums.ac.ir/id/eprint/10677

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