Bone mineral density in Iranian adolescents and young adults with β-thalassemia major

Shamshirsaz, A.A. and Bekheirnia, M.R. and Kamgar, M. and Pakbaz, Z. and Tabatabaie, S.M. and Bouzari, N. and Pourzahedgilani, N. and Azarkeivan, A. and Hashemi, S.R. and Moosavi, F. and Alebouyeh, M. and Vosough, P. and Kimiagar, M. and Shamshirsaz, A.A. and Moradi, M. and Habibzadeh, M.R. and Nobakhthaghighi, N. and Larijani, B. (2007) Bone mineral density in Iranian adolescents and young adults with β-thalassemia major. Pediatric Hematology and Oncology, 24 (7). pp. 469-479.

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Abstract

The authors investigated the prevalence of low bone mass in patients from Tehran, Iran, with β-thalassemia major (n = 203), aged 10-20 years, and the potential risk factors for osteoporosis in this patient population. Prevalence of osteoporosis was 50.7 in lumbar spine, 10.8 in femur, and 7.9 in both regions with no significant difference between the two genders. The following factors were associated with low BMD: height for age and weight for age below 3rd percentile, delayed puberty or hypogonadism, age when Desferal (for iron chelation) was started, duration of Desferal therapy, and serum zinc. Low serum copper and 25(OH)D were not associated with low BMD. Copyright © Informa Healthcare USA, Inc.

Item Type: Article
Additional Information: cited By 22
Uncontrolled Keywords: ascorbic acid; deferoxamine mesylate; zinc, adolescent; adult; age distribution; anamnesis; anthropometry; article; beta thalassemia; blood transfusion; body height; body weight; bone density; bone mass; controlled study; delayed puberty; endocrine disease; female; femur; human; hypogonadism; Iran; iron chelation; lumbar spine; major clinical study; male; metabolic disorder; morbidity; osteopenia; osteoporosis; prevalence; risk assessment; school child; sex difference; thalassemia major; treatment duration; zinc blood level, Adolescent; beta-Thalassemia; Bone Density; Bone Diseases, Metabolic; Child; Female; Fractures, Bone; Humans; Iran; Male; Osteoporosis; Prevalence
Subjects: WH Hemic and Lymphatic Systems
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 09:04
Last Modified: 26 Feb 2019 09:04
URI: http://eprints.iums.ac.ir/id/eprint/10700

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