Design, Synthesis and the inhibitory effects of amino acid derivatives of β-Boswellic acid on Acetylcholinestrase

Esmaeili, S. and Riazi, G.H. and Afrasiabi, A. and Modaresi, S.M.S. and Dadras, A. and Naeini, F.B. and Nezhati, M.N. (2014) Design, Synthesis and the inhibitory effects of amino acid derivatives of β-Boswellic acid on Acetylcholinestrase. International Journal of Pharmaceutical Sciences Review and Research, 28 (1). pp. 200-206.

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Abstract

Extract of gum resins of Boswellia species contains compounds such as β-boswellic acid (BA) that has been identified as the major bioactive ingredients involved in anti-cancer and anti-inflammatory activities as well as the treatment for a broad range of neurodegenerative disorders such as Alzheimer’s disease (AD). The molecular mechanism of advantageous pharmacological effects of such extracts is still not recognized. In this study, we prepared BA coupled with leucine, isoleucine, valine and alanine in alkaline conditions of reaction. Moreover, we evaluated their pharmaceutical efficacy by measuring acetylcholinesterase (AChE) activity. We concluded that some amino acid complexes of BA may be used as potential drugs in the treatment of AD due to suppress AChE activity; however, more in vivo experiments would be needed. © 2014, Global Research Online. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: acetylcholinesterase; alanine; amino acid derivative beta boswellic acid; boswellic acid; carbon; hydrogen; isoleucine; leucine; nitrogen; unclassified drug; valine, adult; Alzheimer disease; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; brain cortex; chemical reaction; drug design; drug synthesis; enzyme active site; enzyme activity; enzyme inhibition; experimental sheep; infrared spectroscopy; male; mass fragmentography; nonhuman; synaptosome; transmission electron microscopy
Subjects: QU Biochemistry. Cell Biology and Genetics
Depositing User: Ms Roya Vesal Azad
Date Deposited: 26 Feb 2019 09:15
Last Modified: 26 Feb 2019 09:15
URI: http://eprints.iums.ac.ir/id/eprint/11795

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