Diagnostic Performance of 64-Channel Multislice Computed Tomography in Assessment of Significant Coronary Artery Disease in Symptomatic Subjects

Shabestari, A.A. and Abdi, S. and Akhlaghpoor, S. and Azadi, M. and Baharjoo, H. and Pajouh, M.D. and Emami, Z. and Esfahani, F. and Firouzi, I. and Hashemian, M. and Kouhi, M. and Mozafari, M. and Nazeri, I. and Roshani, M. and Salevatipour, B. and Tavalla, H. and Tehrai, M. and Zarrabi, A. (2007) Diagnostic Performance of 64-Channel Multislice Computed Tomography in Assessment of Significant Coronary Artery Disease in Symptomatic Subjects. American Journal of Cardiology, 99 (12). pp. 1656-1661.

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Abstract

The recent development of 64-channel multislice computed tomography (MSCT) has resulted in noninvasive coronary artery imaging improvement. This study was conducted to determine the accuracy of 64-slice MSCT in a relatively unselected group of 143 patients with presentations suggestive of coronary artery disease, including those with unstable angina pectoris, who underwent both coronary computed tomographic angiography and invasive coronary angiography. No arrhythmia was considered an exclusion criterion except for atrial fibrillation or frequent extrasystoles. In patients with fast heart rates, a β blocker was administered orally. Data were obtained using electrocardiography gated 64-slice MSCT. Computed tomographic angiography and invasive coronary angiography findings of each coronary segment were compared to determine the sensitivity, specificity, positive predictive value, and negative predictive value of MSCT in the detection of their normalcy or insignificant (<50 diameter decrease) stenosis versus significant (�50 diameter decrease) stenosis or total occlusion. In per-patient assessment, the calculated sensitivity, specificity, positive predictive value, and negative predictive value of MSCT were 96, 67, 91, and 83, respectively. These values in per-artery evaluation were 94, 94, 87, and 97, and corresponding values in per-segment analysis were 92, 97, 77, and 99, respectively. In conclusion, computed tomographic angiography has high diagnostic performance in the assessment of significant coronary artery disease in most patients in a daily routine practice, including those presenting with unstable angina pectoris symptoms. © 2007 Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: cited By 50
Uncontrolled Keywords: beta adrenergic receptor blocking agent, adult; aged; article; computed tomographic angiography; computer assisted tomography; controlled study; coronary artery disease; electrocardiogram; female; heart atrium fibrillation; human; imaging system; major clinical study; male; priority journal, Aged; Angina, Unstable; Coronary Angiography; Coronary Arteriosclerosis; Female; Humans; Male; Middle Aged; Prospective Studies; Tomography, X-Ray Computed
Subjects: WG Cardiovascular System
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 10:50
Last Modified: 26 Feb 2019 10:50
URI: http://eprints.iums.ac.ir/id/eprint/11860

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