Effects of Renal Transplantation on Serum-Free and Total PSA Levels

Kamali, K. and Zargar, M.A. (2007) Effects of Renal Transplantation on Serum-Free and Total PSA Levels. Transplantation Proceedings, 39 (4). pp. 1027-1028.

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Purpose: This study was undertaken to evaluate the effects of renal transplantation on serum level of free and total PSA. Materials and Methods: In this study, we included 30 male patients with a mean age of 46 years with end-stage renal disease undergoing renal transplantation at our department. None of the patients had any history of prostate cancer. All patients had immediate onset of renal function after transplantation, defined by a spontaneous decrease in serum creatinine on postoperative day 1 and a subsequent decrease daily during week 1. Renal transplantation included living-related donors in all patients. Blood samples were obtained before and at posttransplant day 6 before removal of Foley catheter. Measurements of free PSA and total PSA were performed with immunofluorometric assays. Glomerular filtration rates were monitored by analyzing serum creatinine. The significance of changes with time was estimated by the Wilcoxon signed ranks test for paired observations with P < .05 considered statistically significant. Results: The mean free and total PSA levels before transplantion were 0.22 (range, 0.0.05 to 0.4) and 1.5 ng/mL (range, 0.1 to 2.9), respectively. There was a significant decrease (30 of original levels) in serum fPSA at posttransplant day 6 (P < .05) in all patients. There was no significant changes of total PSA at posttransplant day 6. Conclusions: These results verify the hypothesis that free PSA is eliminated from the blood circulation by glomerular filtration and severe renal failure influences its levels. Thus, we should consider different cutoffs for free to total ratio before and after renal transplantation. © 2007 Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: cyclosporin; mycophenolic acid 2 morpholinoethyl ester; prostate specific antigen; steroid, adult; aged; article; balloon catheter; blood sampling; clinical article; controlled study; glomerulus filtration rate; graft versus host reaction; human; immunofluorescence test; kidney failure; kidney function; kidney transplantation; male; postoperative period; priority journal, Adult; Aged; Glomerular Filtration Rate; Humans; Kidney Transplantation; Living Donors; Male; Middle Aged; Prostate-Specific Antigen; Retrospective Studies
Subjects: WJ Urogenital System
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 10:57
Last Modified: 26 Feb 2019 10:57
URI: http://eprints.iums.ac.ir/id/eprint/11881

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