Microchimerism and Renal Transplantation: Doubt Still Persists

Saraji, A. and Pourmand, G. and Mehrsai, A. and Taherimahmodi, M. and Nikoobakht, M. and Asadpour, A. and Nikbin, B. and Tajik, N. and Emamzadeh, A. (2007) Microchimerism and Renal Transplantation: Doubt Still Persists. Transplantation Proceedings, 39 (4). pp. 948-950.

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Abstract

Objective: We sought to study microchimerism in a group of kidney transplant recipients. Materials and Methods: In this study, the peripheral blood microchimerism (PBM) after renal transplantation was retrospectively evaluated in 32 male-to-female recipients of living unrelated or cadaveric donor renal transplants. Using a nested polymerase chain reaction (PCR) amplification specific for SRY region of the Y chromosome, microchimerism was detected with a sensitivity of 1:1,000,000. Recipients were compared according to the presence of PBM, acute and chronic rejection episodes, type of allotransplant, recipient and donor age at transplantation, previous male labor or blood transfusion, allograft function (serum creatinine level), and body mass index. Results: Among 32 recipients, 7 (21.9) were positive for PBM upon multiple testing at various posttransplant times. All microchimeric recipients had received kidneys from living unrelated donors. No significant difference was observed with regard to other parameters. In addition the acute rejection rate in the microchimeric group was 3 (42) versus 4 (16) in the nonmicrochimeric recipients (not significant). Conclusion: Our results suggested better establishment of microchimerism after living donor kidney transplantation. However, doubt persists concerning the true effect of microchimerism after renal transplantation. It seems that microchimerism alone has no major protective role upon renal allograft survival. © 2007 Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: azathioprine; creatinine; cyclosporin; mycophenolic acid 2 morpholinoethyl ester; prednisolone, acute graft rejection; article; blood analysis; blood transfusion; body mass; cadaver donor; chronic graft rejection; clinical article; controlled study; creatinine blood level; female; graft recipient; human; kidney donor; kidney graft rejection; kidney transplantation; living donor; male; microchimerism; polymerase chain reaction; priority journal; sensitivity analysis; Y chromosome, Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunosuppression; Kidney Transplantation; Male; Reproducibility of Results; Retrospective Studies; Transplantation Chimera
Subjects: WJ Urogenital System
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 10:57
Last Modified: 26 Feb 2019 10:57
URI: http://eprints.iums.ac.ir/id/eprint/11884

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