Preliminary report of a nationwide case-control study for identifying risk factors of tuberculosis following renal transplantation

Basiri, A. and Hosseini Moghaddam, S.M.M. and Simforoosh, N. and Einollahi, B. and Hosseini, M. and Foirouzan, A. and Pourrezagholi, F. and Nafar, M. and Zargar, M.A. and Pourmand, G. and Tara, A. and Mombeni, H. and Moradi, M.R. and Taghizadeh, A. and Gholamrezaee, H.R. and Bohlouli, A. and Nezhadgashti, H. and Amirzadehpasha, A. and Ahmad, E. and Salehipour, M. and Yazdani, M. and Nasrollahi, A. and Falaknazi, K. and Mahdavi, M.R. and Shamsa, A. and Feizzadeh, B. and Mojahedi, M.J. and Oghbaee, N. and Esmaeeli Azad, R. and Mohammadi, Z. (2005) Preliminary report of a nationwide case-control study for identifying risk factors of tuberculosis following renal transplantation. Transplantation Proceedings, 37 (7). pp. 3041-3044.

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Transplantation Proceedings Volume 37 issue 7 2005 [doi 10.1016_j.transproceed.2005.07.041] A. Basiri; S.M.M. Hosseini Moghaddam; N. Simforoosh; B. Einollah -- Preliminary Report of a Nationwide Cas.pdf

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Abstract

Background. Tuberculosis (TB) is an important infection encountered posttransplantation, especially among patients in developing countries, where there are high incidences of morbidity and mortality. Materials and Methods. One hundred and twenty subjects (1) from 15 major kidney transplantation centers in Iran from 1984 to 2003 were compared with 440 controls who were matched for operative time, treatment center, and surgical team. Results. Mean ages of research subjects and controls were 38.6 and 36.6 years (P = .04), respectively. The mean duration of pretransplantation hemodialysis was 29 months (range, 2 to 192 months) in research subjects and 20 months (range, 1 to 180 months) in controls (P = .003). Positive past history of tuberculosis was detected in 4 (3.3) research subjects and in 7 (1.5) controls (P = .2). Fifty-two research subjects (43.3) and 241 controls (54.8) had pretransplantation purified protein derivative of tuberculin less than 5 mm (P = .02). Mean dosages of initial and maintenance immunosuppressive drugs in research subjects and in controls were not significantly different. Sixty research subjects (50) and 152 controls (34.5) had rejection prior to diagnosis of TB (P = .03). Conclusion. To our knowledge, this is the first study that demonstrates an increased risk of posttransplant TB by prolonged duration of pretransplant hemodialysis and number of posttransplant rejection episodes. Further study is needed to clarify these findings specifically with respect to various immunosuppressive regimens. © 2005 by Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: cited By 32
Uncontrolled Keywords: azathioprine; cyclosporin A; ethambutol; isoniazid; lymphocyte antibody; methylprednisolone; mycophenolic acid 2 morpholinoethyl ester; OKT 3; prednisolone; pyrazinamide; rifampicin; steroid; thymocyte antibody; tuberculin; tuberculostatic agent, adolescent; adult; aged; article; case control study; child; controlled study; drug blood level; female; hemodialysis; human; Iran; kidney graft rejection; kidney transplantation; maintenance therapy; major clinical study; male; Mycobacterium tuberculosis; operation duration; preoperative care; priority journal; protein purification; risk factor; tuberculosis, Adolescent; Adult; Aged; Case-Control Studies; Child; Child, Preschool; Developing Countries; Female; Humans; Infant; Iran; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Patient Care Team; Postoperative Complications; Recurrence; Renal Dialysis; Retrospective Studies; Tuberculosis
Subjects: WO Surgery
WJ Urogenital System
Depositing User: Librarian Farzaneh Dini
Date Deposited: 12 May 2019 09:27
Last Modified: 12 May 2019 09:27
URI: http://eprints.iums.ac.ir/id/eprint/12135

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