Pruritus in hemodialysis patients

Akhyani, M. and Ganji, M.-R. and Samadi, N. and Khamesan, B. and Daneshpazhooh, M. (2005) Pruritus in hemodialysis patients. BMC Dermatology, 5.

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BMC Dermatology Volume 5 issue 1 2005 [doi 10.1186_1471-5945-5-7] Maryam Akhyani; Mohammad-Reza Ganji; Nasrin Samadi; Behnaz Khame -- Pruritus in hemodialysis patients.pdf

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Abstract

Background: Pruritus is one of the most bothersome symptoms in patients on maintenance hemodialysis (HD), however little progress is seen in our understanding of its pathogenesis. The aim of this study was to evaluate the frequency of pruritus in HD patients in Tehran, Iran, and to correlate its presence and intensity with relevant clinical and laboratory parameters. Methods: One hundred sixty-seven patients on maintenance HD at three out-patient HD units were enrolled in the study. Itch intensity was scored as mild, moderate and severe. Some relevant clinical and laboratory parameters (age, sex, xerosis, presence of neuropathy, duration of dialysis, history of atopy and laboratory findings including hematocrit, creatinine, urea, calcium, phosphorus, parathyroid hormone PTH and alkaline phosphatase) were evaluated. Results: Pruritus was found in 41.9% of patients. The intensity of itching was mild, moderate and severe, in 51.4%, 11.4% and 37.7% of patients, respectively. In 22 patients (31.4%) pruritus intensified during and after dialysis. There was no significant difference in the serum levels of creatinine, blood urea nitrogen, calcium, phosphorus, alkaline phosphatase, PTH and hematocrit between patients with and without pruritus. Age, sex, xerosis, underlying renal disease, history of atopy and duration of haemodialysis were not significantly different between the two groups. However, neuropathy was significantly more common in the pruritic group (63.8% versus 42.1%) (pv = 0.006). Conclusion: Clinical neuropathy was the only significant finding in the pruritic group in our study. This finding justifies further research on nerve function and neurotransmitters in hemodialysis patients and the introduction of new drugs targeting neuropathy. © 2005 Akhyani et al; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: cited By 47
Uncontrolled Keywords: alkaline phosphatase; calcium; creatinine; parathyroid hormone; phosphorus, adolescent; adult; aged; article; atopy; controlled study; correlation analysis; disease association; disease severity; female; hematocrit; hemodialysis; human; Iran; laboratory test; major clinical study; male; neuropathy; population distribution; pruritus; school child; scoring system; statistical analysis; statistical significance; urea nitrogen blood level; xerosis; child; middle aged; peripheral neuropathy; pruritus; renal replacement therapy; severity of illness index; skin disease; uremia, Adolescent; Adult; Aged; Child; Female; Humans; Iran; Male; Middle Aged; Peripheral Nervous System Diseases; Pruritus; Renal Dialysis; Severity of Illness Index; Skin Diseases; Uremia
Subjects: WJ Urogenital System
Depositing User: Librarian Farzaneh Dini
Date Deposited: 12 May 2019 09:33
Last Modified: 12 May 2019 09:33
URI: http://eprints.iums.ac.ir/id/eprint/12149

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