Effect of subchronic administration of aqueous Artemisia annua extract on α1-adrenoceptor agonist-induced contraction of isolated aorta in rat

Mojarad, T.B. and Roghani, M. and Zare, N. (2005) Effect of subchronic administration of aqueous Artemisia annua extract on α1-adrenoceptor agonist-induced contraction of isolated aorta in rat. Iranian Biomedical Journal, 9 (2). pp. 57-62.

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Abstract

Artemisia species, growing in almost all the northern hemisphere, is used in folk medicine of some countries as a remedy for hypertension. Since some cardiovascular disorders including hypertension are accompanied with altered responsiveness of vascular alpha-adrenergic receptors, the effect of aqueous Artemisia annua extract (100 and 200 mg kg-1) on α1- adrenoceptor agonist-induced contraction of rat aorta was investigsted. After 4 weeks, the contraction and endothelium-dependent and -independent relaxation response of extract-treated rats were recorded. The results showed that the contractile response of aortic rings with endothelium to phenylephrine in extract-treated rats decreases (P<0.1-0001) and their endothelium-dependent relaxation response to acetylcholine increases (P<0.01-0.001) significantly in comparison with controls. Endothelium-denuded aortic rings from extract-treated rats also showed a significant decrease (P<0.05) in contractile response, but there was no considerable difference in their endothelium-independent relaxation response to isosorbide dinitrate. These data suggest that the aqueous extract of Artemisia annua could attenuate contractile response and enhance the endothelium-dependent relaxation response of aortic rings from normal rats.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: acetylcholine; alpha 1 adrenergic receptor stimulating agent; Artemisia annua extract; isosorbide dinitrate; phenylephrine, animal cell; animal experiment; animal model; animal tissue; aorta constriction; Artemisia; article; cardiovascular disease; controlled study; drug effect; hypertension; male; nonhuman; rat; traditional medicine; vascular ring, Animalia; Artemisia; Artemisia annua
Subjects: QV Pharmacology
Depositing User: Librarian Farzaneh Dini
Date Deposited: 04 May 2019 06:10
Last Modified: 04 May 2019 06:10
URI: http://eprints.iums.ac.ir/id/eprint/12174

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