An open trial of citalopram in children and adolescents with depression

Shirazi, E. and Alaghband-Rad, J. (2005) An open trial of citalopram in children and adolescents with depression. Journal of Child and Adolescent Psychopharmacology, 15 (2). pp. 233-239.

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Journal of Child and Adolescent Psychopharmacology Volume 15 issue 2 2005 [doi 10.1089_cap.2005.15.233] Shirazi, Elham; Alaghband-Rad, Javad -- An Open Trial of Citalopram in Children and Adolescent.pdf

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Abstract

Objective: The aim of this study was to collect pilot data on the magnitude of effect and tolerability of citalopram in early-onset major depressive disorder (MDD). Method: This study was performed in two academic child and adolescent psychiatric clinics (2000 through 2002). Thirty children and adolescents, 8-17 years of age (mean age, 13.57 ± 2.5), of both sexes (53.3 girls; 46.7 boys) and diagnosed with MDD by means of clinical psychiatric evaluation, Diagnostic Interview for Children and Adolescents (DICA) and the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria, were studied in an open-label clinical trial with 10-40 mg/day of citalopram for 6 weeks. The out-come measures were the Hamilton Depression Rating Scale (HDRS), the Children Global Assessment Scale (CGAS), and the New York State Psychiatric Institute side-effect form. Results: Moderate (50-70 change in HDRS and CGAS) to large (> 70 change in HDRS and CGAS) effect were seen in 91.7 of children (22/24). There were significant changes on HDRS (X = 22.78; t = -14.12; p < 0.000) and CGAS (X = 26.02; t = 9.68; p < 0.000) between base-line and the 6th week. Mild side effects were reported in 2 patients (8.3). Adverse effects that contributed to discontinuation were nausea and vomiting in 3.3 (n = 1) of patients and unexpectedly switching to mania in 16.7 (n = 5) of patients. Conclusion: Citalopram may be an efficatious treatment in early-onset MDD. However, the high switch rate to mania warrants further investigations, as well as cautions, in using it.

Item Type: Article
Additional Information: cited By 14
Uncontrolled Keywords: citalopram, adolescent; article; child; clinical article; clinical trial; drug tolerability; female; Hamilton scale; human; interview; major depression; male; mania; nausea; pilot study; vomiting, Adolescent; Child; Citalopram; Depressive Disorder, Major; Female; Humans; Male; Pilot Projects
Subjects: WM Psychiatry
QV Pharmacology
Depositing User: Librarian Farzaneh Dini
Date Deposited: 04 May 2019 07:26
Last Modified: 04 May 2019 07:26
URI: http://eprints.iums.ac.ir/id/eprint/12176

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