Expression of neuronal nitric oxide synthase during embryonic development of the rat optic vesicle

Nobakht, M. and Majidzadeh, S. and Fattahi, M. and Samadi, M. and Tabatabaeei, P. (2007) Expression of neuronal nitric oxide synthase during embryonic development of the rat optic vesicle. Pakistan Journal of Biological Sciences, 10 (7). pp. 1078-1082.

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Abstract

The expression of neuronal nitric oxide synthase during the development of rat optic vesicle from embryonic day E14 to E18 was analyzed by histochemical procedures. The samples were frozen and cut on a cryostat and then studied by using the light microscope. Expression of nNOS was first seen on E14 in cells of Cajal-Retzius located in the marginal zone of optic vesicle. NADPH-d persisted in this layer throughout the embryonic period and began to decrease on E20. At E16, the optic vesicle has four NADPH-d positive layers. At E18, NADPH-d reactivity observed at low magnification showed five clearly defined layers. In the late stages, the most notable feature was a decrease in histochemical reaction of the marginal zone and at these stages, the layer IV showed less staining than the rest of the cortical plate. The observations suggest that nitric oxide is synthesized during embryonic life processes and this is related to maturational processes. © 2007 Asian Network for Scientific Information.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: Rattus
Subjects: QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:03
Last Modified: 26 Feb 2019 11:03
URI: http://eprints.iums.ac.ir/id/eprint/12229

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