Pimecrolimus cream in repigmentation of vitiligo

Seirafi, H. and Farnaghi, F. and Firooz, A. and Vasheghani-Farahani, A. and Alirezaie, N.-S. and Dowlati, Y. (2007) Pimecrolimus cream in repigmentation of vitiligo. Dermatology, 214 (3). pp. 253-259.

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Background: Vitiligo is a chronic disease that mostly affects children and young adults. Nowadays many treatment options are available; however, most of them have limited efficacy and in most cases would result in undesirable complications. Objective: To determine the extent of repigmentation according to the location of the lesions after applying topical cream pimecrolimus 1 in vitiligo patients. Materials and Methods: Thirty consecutive patients with vitiligo lesions affecting less than 20 of body surface area without any previous history of spontaneous repigmentation were treated with pimecrolimus cream 1 twice daily for 12 weeks. The extent of repigmentation in vitiligo lesions was determined in each patient after 6 and 12 weeks. Results: Moderate to excellent response (repigmentation >26) was observed in 6.6 and 25.9 of vitiligo lesions 6 and 12 weeks after treatment, respectively. More responsive lesions were located on the trunk, face and elbow (85.7, 75 and 70). Conclusion: Pimecrolimus cream 1 results in repigmentation in vitiligo in different extents according to the location of the lesion; however, to clearly prove its efficacy as monotherapy or in combination with other available treatment options, double-blind placebo-controlled studies are essential. Copyright © 2007 S. Karger AG.

Item Type: Article
Additional Information: cited By 16
Uncontrolled Keywords: pimecrolimus, adolescent; adult; article; body surface; burning sensation; clinical article; clinical trial; cream; female; human; male; pigmentation; priority journal; school child; therapy effect; treatment duration; treatment response; vitiligo, Adolescent; Adult; Child; Dermatologic Agents; Humans; Middle Aged; Ointments; Skin Pigmentation; Tacrolimus; Vitiligo
Subjects: WR Dermatology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:14
Last Modified: 26 Feb 2019 11:14
URI: http://eprints.iums.ac.ir/id/eprint/12243

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