Antiviral effect assay of twenty five species of various medicinal plants families in Iran

Ziai, S.A. and Hamkar, R. and Monavari, H.R. and Norooz-Babaei, Z. and Adibi, L. (2007) Antiviral effect assay of twenty five species of various medicinal plants families in Iran. Journal of Medicinal Plants, 6 (SUPPL.). 1-9+70.

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Background: Medicinal plants have been traditionally used for different kinds of ailments including infectious diseases. There is an increasing need for substances with antiviral activity since the treatment of viral infections with the available antiviral drugs often leads to the problem of viral resistance. There is a need to search for new and more effective antiviral agents. Objective: therefore in the present study 20 plants with ethno-medical background from different families were screened for antiviral activity against HSV-1, Adenovirus type 5, Echovirus type 11, Measles virus and Rotavirus. Methods: Different parts of the plants collected from Iran were extracted with aqueous solvents to obtain crude extracts. These extracts were screened for their cytotoxicity against Vero, BSC-1, Hep-II and RD cell lines by assays micro-culture neutral red dye absorption and microscopically follow up for CPE. Antiviral properties of the plant extracts were determined by cytopathic effect inhibition assay and plaque reduction assay. Results: Three plants extract; Aristolochia maurorum, Terminalia chebula Retz. and Cichorium intybus L. exhibited significant antiviral activity against HSV-1 and adenovirus type 5 at a concentration non toxic to the cell lines used. The extracts of Aristolochia maurorum and Cichorium intybus L. showed great anti viral activity against HSV-1 and partial activity against adenovirus at higher concentrations. Conclusion: Some of the medicinal plants have shown antiviral activity. Further research is needed to elucidate the active constituents of these plants which may be useful in the development of new and effective antiviral agents.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: Aristolochia maurorum extract; cichorium intybus extract; plant extract; Terminalia chebula extract; unclassified drug, Adenovirus 5; antiviral activity; article; controlled study; cytotoxicity; drug activity; Echo virus; Herpes simplex virus 1; Iran; medicinal plant; nonhuman; Rotavirus, Adenoviridae; Aristolochia maurorum; Cichorium intybus; Human adenovirus type 5; Human echovirus 11; Human herpesvirus 1; Measles virus; Rotavirus; Terminalia chebula
Subjects: QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:15
Last Modified: 26 Feb 2019 11:15

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