The effect of L-carnitine on serum nitric oxide level and angiotensin converting enzyme activity in STZ - Induced diabetic and normal rats

Sharifi, A.M. and Ghaderpanahi, M. and Mazhari, S.Z.H. (2007) The effect of L-carnitine on serum nitric oxide level and angiotensin converting enzyme activity in STZ - Induced diabetic and normal rats. Iranian Journal of Diabetes and Lipid Disorders, 6 (3). 21-29+E28.

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Abstract

Background: Cardiovascular disease including hypertension are complications of long-standing diabetes. A few Studies had shown the positive effects of L-carnitine on hypertension. In this study, the possible effects of L-carnitne on nitric oxide (NO) levels and angiotensin-converting enzyme (ACE) activity in serum as well as systolic blood pressure (SBP) in diabetic and normal rats were studied. Methods: In this study forty rats were used in four groups including non-treated control (C), L-carnitne treated control (CT), diabetic (D) and L-carnitne treated diabetic (DT). Diabetes was induced in rats by injection of stereptozotosin. Both of C & D groups had a free access to food and water and CT & DT groups were received daily dose of L-carnation in drinking water. At the end of 12 weeks SBP, serum NO and ACE activity were measured. Results: Systolic blood pressure was significantly decreased in DT group compared to D group. Serum ACE activity was also significantly decreased in DT group compared to D group and the serum NO levels were significantly increased in DT & CT groups compared to D & C groups respectively. Conclusion: Finally it could be concluded that L-carnitine may reduce SBP in diabetic rats via elevation of serum NO levels and reduction of serum ACE activity.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: carnitine; dipeptidyl carboxypeptidase; nitric oxide; streptozocin, animal experiment; article; controlled study; diabetes mellitus; drug blood level; enzyme activity; nonhuman; rat; systolic blood pressure
Subjects: QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:17
Last Modified: 26 Feb 2019 11:17
URI: http://eprints.iums.ac.ir/id/eprint/12251

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