Effect of chronic lithium administration on endothelium-dependent relaxation of rat corpus cavernosum: The role of nitric oxide and cyclooxygenase pathways

Sadeghipour, H. and Ghasemi, M. and Nobakht, M. and Ebrahimi, F. and Dehpour, A.R. (2007) Effect of chronic lithium administration on endothelium-dependent relaxation of rat corpus cavernosum: The role of nitric oxide and cyclooxygenase pathways. BJU International, 99 (1). pp. 177-182.

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Abstract

OBJECTIVE: To verify the effect of chronic lithium administration on the endothelium-dependent relaxation of rat corpus cavernosum, as lithium is a major drug for treating bipolar disorder and some studies showed that lithium might cause erectile dysfunction in such patients, by a mechanism as yet unknown. MATERIALS AND METHODS: LiCl (600 mg/L) was dissolved in drinking water and Sprague-Dawley rats received the solution for 30 days; control rats received tap water. After 30 days corporeal strips were prepared from both groups, mounted under tension in oxygenated organ baths, and pre-contracted with phenylephrine (7.5 μm). After equilibration, the strips were relaxed by acetylcholine (10 nm to 1 mm) in the presence or absence of indomethacin (a cyclooxygenase inhibitor; 20 μm). Furthermore, the relaxant responses to sodium nitroprusside (1 nm to 1 mm), a nitric oxide (NO) donor, were investigated in both groups. NADPH-diaphorase histochemistry was used to identify NO synthase within cavernosal tissue strips of both groups. RESULTS: The acetylcholine-dependent relaxation was significantly lower in lithium-treated rats than in controls. Although indomethacin decreased significantly the relaxant responses to acetylcholine in controls, it increased the relaxant responses in lithium-treated rats. NADPH-diaphorase staining was greater in the chronic lithium-treated than in control preparations. Sodium nitroprusside produced similar relaxation in both groups. CONCLUSION: Chronic lithium administration can impair the endothelium-dependent relaxation of rat corpus cavernosum; NO availability might decrease after lithium administration and the cyclooxygenase pathways might have a role in this effect. © 2006 The Authors.

Item Type: Article
Additional Information: cited By 18
Uncontrolled Keywords: endothelium derived relaxing factor; indometacin; lithium; nitric oxide; nitroprusside sodium; prostaglandin synthase, animal experiment; animal tissue; article; controlled study; corpus cavernosum; drug blood level; drug effect; endothelium; erectile dysfunction; male; muscle relaxation; nonhuman; priority journal; rat; staining, Animals; Antimanic Agents; Endothelium; Impotence, Vasculogenic; Lithium Chloride; Male; Muscle Relaxation; Nitric Oxide; Nitric Oxide Synthase; Penile Erection; Penis; Phenylephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents
Subjects: QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:40
Last Modified: 26 Feb 2019 11:40
URI: http://eprints.iums.ac.ir/id/eprint/12295

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