Nimodipine protects PC12 cells against oxygen-glucose deprivation

Rahbar-Roshandel, N. and Razavi, L. and Tavakoli-Far, B. (2007) Nimodipine protects PC12 cells against oxygen-glucose deprivation. Iranian Journal of Pharmacology and Therapeutics, 6 (1). pp. 51-54.

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The protective effect of an L-type calcium channel blocker, nimodipine, on cell injury induced by oxygenglucose deprivation (OGD) in PC12 cells was investigated. PC12 cells were exposed to oxygen-glucose deprivation (30 minutes and 60 minutes respectively) in the presence or absence of nimodipine (10μM/L) in three different time schedules (pre-24h, pre-3h and concurrently). Cellular viability was assessed by MTT assay. OGD-induced cell injury was significantly attenuated by nimodipine in all three treatment schedules. Application of MK801 (10μM/L), an antagonist of NMDA glutamate receptors also inhibited PC12 cell death induced by OGD. Our study suggests that nimodipine has protective effects against OGD-induced neurotoxicity. Copyright © 2006 by Razi Institute for Drug Research (RIDR).

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: dizocilpine; glucose; n methyl dextro aspartic acid receptor; nimodipine; oxygen, animal cell; article; cell assay; cell damage; cell hypoxia; cell protection; cell strain; cell viability; chronology; drug effect; nonhuman; rat; receptor upregulation
Subjects: QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:48
Last Modified: 26 Feb 2019 11:48

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