Frequency of paraoxonase 192/55 polymorphism in an Iranian population

Sepahvand, F. and Rahimi-Moghaddam, P. and Shafiei, M. and Ghaffari, S.M. and Rostam-Shirazi, M. and Mahmoudian, M. (2007) Frequency of paraoxonase 192/55 polymorphism in an Iranian population. Journal of Toxicology and Environmental Health - Part A: Current Issues, 70 (13). pp. 1125-1129.

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Abstract

Paraoxonase (PON1) is a serum enzyme that plays an important role in prevention of atherosclerosis and also protects against organophosphate-induced neurotoxicity. PON1 displays a high variablility in human populations. In this study, PON1-192 and -55 polymorphisms and correlation to serum PON1 activity were investigated in 132 healthy Iranian individuals from Isfahan province. The genotype frequencies for PON1-192 were approximately 48 (QQ), 42. (QR), and 10 (RR) and for PON1-55 17 (MM), 48 (ML), and 35 (LL). Thus, the frequencies of alleles R and L were 0.31 and 0.59, respectively. PON1 activity toward paraoxon was markedly affected in both polymorphic populations in the following order QQ < QR < RR genotype for PON1-192 and MM < ML < LL genotype for PON1-55. Neither polymorphism significantly affected PON1 activity toward phenylacetate. The RR/LL individuals had the highest PON1 activity and QQ/MM individuals the least. The QR/ML haplotype was the most frequent seen in Iranians, and the RR/MM and QR/MM haplotypes were absent in this population. In conclusion, the frequencies of PON1-192 and -55 polymorphisms in this Iranian population were different from those seen in other Asian populations from Japan and China but similar to those for European Caucasians. Copyright © Taylor & Francis Group, LLC.

Item Type: Article
Additional Information: cited By 13
Uncontrolled Keywords: aryldialkylphosphatase; phenylacetic acid, adolescent; adult; aged; article; Asian; controlled study; correlation analysis; enzyme activity; female; gene frequency; genetic polymorphism; genotype; haplotype; human; Iran; male; normal human; priority journal; statistical significance, Adolescent; Adult; Aged; Aryldialkylphosphatase; Atherosclerosis; Female; Genetics, Population; Genotype; Humans; Iran; Male; Middle Aged; Phosphoric Acid Esters; Polymorphism, Genetic
Subjects: QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:49
Last Modified: 26 Feb 2019 11:49
URI: http://eprints.iums.ac.ir/id/eprint/12310

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