The risk factors of prostate cancer: A multicentric case-control study in Iran

Pourmand, G. and Salem, S. and Mehrsai, A. and Lotfi, M. and Amirzargar, M.A. and Mazdak, H. and Roshani, A. and Kheirollahi, A. and Kalantar, E. and Baradaran, N. and Saboury, B. and Allameh, F. and Karami, A. and Ahmadi, H. and Jahani, Y. (2007) The risk factors of prostate cancer: A multicentric case-control study in Iran. Asian Pacific Journal of Cancer Prevention, 8 (3). pp. 422-428.

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Abstract

Prostate cancer (PC), in Iran, is the third most frequently diagnosed visceral cancer among men and the seventh most common underlying cause of cancer mortality. We evaluated the relation between speculated factors and PC risk using data from a multicentric case-control study conducted in Iran from 2005 to 2007 on 130 cases of incident, clinicopathologically confirmed PC, and 75 controls admitted to the same network of hospitals without any malignant disease. Odds ratios(OR) and corresponding 95 confidence intervals (CIs) were estimated using conditional logistic regression models. The risk of PC was increased with aging (OR: 5.35, 95 CI: 2.17-13.19; P<0.0001), and with the number of sexual intercourse �2 times/week (OR: 3.14, 95 CI: 1.2-8.2; P=0.02). One unit elevation in serum estradiol and testosterone concentration was related to increase (OR: 1.04, 95 CI: 1.01-1.06; P=0.006) and decrease (OR: 0.79; 95 CI: 0.64-0.96; P=0.02) of PC risk, respectively. Cases were less likely to have a history of diabetes (OR: 0.34, 95 CI: 0.12-0.98; P=0.04). Increasing in dietary consumption of lycopene and fat was associated with declined (OR: 0.45, 95 CI: 0.09-2.12) and increased (OR: 2.38, 95 CI: 0.29-19.4) PC development, respectively. Other factors including educational level, marriage status, dietary meat consumption, vasectomy and smoking have not been shown to affect PC risk in the Iranian population. Ourstudy adds further information on the potential risk factors of PC and is the first epidemiologic report from Iran. However, justification of these results requires more well-designed studies with a larger number of participants.

Item Type: Article
Additional Information: cited By 44
Uncontrolled Keywords: aged; article; case control study; clinical trial; human; Iran; male; middle aged; multicenter study; prospective study; prostate tumor; risk factor; statistical model, Aged; Aged, 80 and over; Case-Control Studies; Humans; Iran; Logistic Models; Male; Middle Aged; Prospective Studies; Prostatic Neoplasms; Risk Factors
Subjects: WJ Urogenital System
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:51
Last Modified: 26 Feb 2019 11:51
URI: http://eprints.iums.ac.ir/id/eprint/12317

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