The efficacy of Sublingual Buprenorphine in controlling pain After cesarean Surgery under Spinal Anesthesia

IsazadeFar, khatere and ghazi, Ahmad and entezariasl, masood and vakili, ay (2019) The efficacy of Sublingual Buprenorphine in controlling pain After cesarean Surgery under Spinal Anesthesia. Anesthesiology and Pain, 9 (4). pp. 15-28.

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 Aims and background: One of the major challenges in women’s surgery, including cesarean section, is postoperative pain control. Postoperative pain as one of the most common problems in the postoperative phase and can lead to a significant reduction in the quality of surgical operations, along with other problems such as nausea and vomiting, hypotension and shivering. Therefore, the present study we aimed to study the efficacy of sublingual Buprenorphine in postoperative pain control following cesarean surgery and its effects among patients. Materials and Methods: The present study is a randomized, double-blind clinical trial. Patients aged 1845years old and all candidates underwent cesarean section at Alavi Hospital in Ardabil in 2017. After obtaining consent from patients for inclusion in the study, 80 patients were selected using simple sampling method and divided into two groups of 40. In the first group,) control group) 40 patients received fentanyl and placebo tablets, and the pump was used to inject intravenous fentanyl and the drug lasted for up to 24 hours. the second group )40 patients) received normal saline pump and buprenorphine pills. In the second group (sublingual buprenorphine + placebo pump), it was repeated 6 and 12 hours after the first dose. Then, VRS pain scores, vomiting  nausea, sedation )from Ramsay sedation scale), and the amount of analgesic demand for pain control at 2, 6, 12, and 24 hours, and postoperative analgesia (time to first need analgesia) were recorded. Finally, all patient information entered into a pre-designed checklist and all the data entered into the SPSS v20 statistical analysis program and we analyzed the data. Findings: In this study, 80 patients were evaluated in two groups The results of VRS pain score in patients showed that, except within 24 hours after surgery, in other hours of study, the pain score in the two groups did not show any significant difference. In the control group, the demand for analgesics was higher than the buprenorphine group. In the early hours after surgery (hours 2 and 6), the incidence of nausea and vomiting was significantly lower in the buprenorphine group than in the control group, but the rest of  it, no difference was observed. The sedation score was also evaluated, but no significant difference was observed in the two groups. Also, the incidence of other side effects in the two groups did not differ significantly. Conclusion: The results of this study showed that buprenorphine is an effective drug in reducing postoperative pain in postoperative patients and, due to its very low side effects, can be routinely used in patients.

Item Type: Article
Uncontrolled Keywords: Regional, anesthesia, Caesarean section, Buprenorphine, Fentanyl.
Subjects: WP Gynecology
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 12 Jun 2019 13:08
Last Modified: 18 Jun 2019 05:50

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