Pharmacokinetics of mebudipine, a new calcium antagonist, following single intravenous and oral administrations in rats.

Bohlooli, Shahab and Keyhanfar, Fariborz and Mahmoudian, Massoud (2004) Pharmacokinetics of mebudipine, a new calcium antagonist, following single intravenous and oral administrations in rats. Biopharmaceutics & drug disposition, 25 (4). pp. 187-91. ISSN 0142-2782

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Abstract

The pharmacokinetics of a new calcium antagonist, mebudipine, was studied after a single intravenous (0.5 mg/kg) and oral (10 mg/kg) administration to rats. After intravenous dosing, the plasma concentration of mebudipine declined biexponentially with a terminal half-life of 2.84 h. The blood clearance was 1.67 l/h/kg and the volume of distribution at steady state was found to be 6.26 l/kg. After oral dosing (10 mg/kg), the C(max) of mebudipine was 25.9+/-9.79 ng/ml. The oral bioavailability was low (< 2%) suggesting a marked first-pass effect. The distribution of mebudipine into some tissues such as brain, heart, liver and kidney following intravenous administration (0.5 mg/kg) was studied and a rapid distribution of mebudipine into these tissues was found. It was concluded that brain, heart, liver and kidney are in the same compartment as plasma (central).

Item Type: Article
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 09:58
Last Modified: 19 Jul 2017 09:58
URI: http://eprints.iums.ac.ir/id/eprint/19

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