Commentary on prevention a possible drug�drug interaction: Is concurrent administration of orlistat and pioglitazone increase the risk of durg�induced hepatotoxicity?

Emzhik, M. and Rahimi-Moghaddam, P. and Ebrahimi, S.A. and Keyhanfar, F. and Moazzam, A.S. (2015) Commentary on prevention a possible drug�drug interaction: Is concurrent administration of orlistat and pioglitazone increase the risk of durg�induced hepatotoxicity? International Journal of Preventive Medicine, 2015-F.

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Abstract

Background: Drug-drug interactions (DDIs) are an emerging threat to public health and are difficult to detect. To prevent DDIs and their burden, the possible DDIs should be kept in mind. We know that the obesity predisposes to the development of insulin resistance and type 2 diabetes. Therefore, combinational uses of antiobesity drugs and glucose? lowering drugs are very common. As the hepatotoxicity of both pioglitazone (an antidiabetic drug) and orlistat (an antiobesity drug) has been shown in some cases, the aim of this study was to evaluate the interaction of pioglitazone and orlistat in human hepatocellular cell line human hepatocellular carcinoma (HepG2) cells to determine their effect on liver toxicity. Methods: Human hepatocellular carcinoma cells were treated with 25 µM Pioglitazon (Pio), 20 µ Orlistat (Orl) pioglitazone, orlistat or combination of them. The MTT assay was used to assess cell viability. Results: Pioglitazone and orlistat combination caused a loss of HepG2 cell viability. While pioglitazone (25 µ and orliatat (20 µ alone decreased the cell viability around 91 and 85 respectively (notsignificant, P> 0.05), the combination of these two drugs reduced the amount of viable cells to 55 which was significant when compared with each drug alone (P < 0.001). Conclusions: Revealing the significant loss of viability of HepG2 cells in the combination use of pioglitazone and orlistat indicates these two drugs should not be administered at the same time to prevent their hepatotoxic effects especially in patients with liver dysfunction. © 2015 Emzhik M.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide; pioglitazone; tetrahydrolipstatin, adverse outcome; Article; cell assay; cell loss; cell viability; controlled study; drug effect; drug potentiation; HepG2 cell line; human; human cell; in vitro study; liver dysfunction; liver toxicity; risk assessment
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/28

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