Adding intra-articular growth hormone to platelet rich plasma under ultrasound guidance in knee osteoarthritis: A comparative double-blind clinical trial

Rahimzadeh, P. and Imani, F. and Faiz, S.-H.-R. and Alebouyeh, M.-R. and Azad-Ehyaei, D. and Bahari, L. and Memarian, A. and Kim, K.-H. (2016) Adding intra-articular growth hormone to platelet rich plasma under ultrasound guidance in knee osteoarthritis: A comparative double-blind clinical trial. Anesthesiology and Pain Medicine, 6 (6).

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Abstract

Introduction: Intra-articular injections of platelet rich plasma (PRP) for the treatment of knee osteoarthritis have been shown to reduce pain and improve joint function. The aim of this study is to examine the joint function by adding intra-articular growth hormoneto platelet rich plasma. This study was performed on the individuals with knee osteoarthritis and under ultrasound guidance. Methods: Fifty four patients who were scheduled for ultra-sound guided intra-articular injection were enrolled in the study. The patients were randomly allocated to groups P (platelet rich plasma) and PS (platelet rich plasma and Somatropin). Group P and PS were injected with 5 mL of platelet rich plasma, and 4 IU growth hormone (Somatropin) added to platelet rich plasma, respectively. Intra-articular injection was performed in two steps; the onset of study and one month after. Knee joint function based onWestern Ontario and McMaster osteoarthritis index (WOMAC) score at the baseline, 1 and 2 month later, and complications were evaluated. Results: WOMAC score in both groups has been significantly reduced after injections (P = 0.030). WOMAC score reduction in group PS in firstmonthwassignificantly higher thangroupP, but in secondmonth2, the differencebetweentwogroupswasnot significant (P = 0.235). No complication was observed. Conclusions: These results showed that adding growth hormone to platelet rich plasma for intra-articular injection improved function of the osteoarthritic knee joint in short period of time. © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM).

Item Type: Article
Additional Information: cited By 1
Depositing User: eprints admin
Date Deposited: 16 Jul 2018 04:52
Last Modified: 16 Jul 2018 04:52
URI: http://eprints.iums.ac.ir/id/eprint/2938

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