The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture

Monavari, S.H. and Parsa, M.J.M. and Bolouri, B. and Ebrahimi, S.A. and Ataei-Pirkooh, A. (2014) The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture. Medical Journal of the Islamic Republic of Iran, 28 (1).

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Abstract

Background: Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture. Methods: In-vitro cytotoxicity study of empty niosomes (E-N), acyclovir loaded niosomes (ACV-N) and ACV as a free drug against HeLa cell line was performed by MTT assay and the viral titers was tested by TCID50 assay. Results: The results indicated that a significant higher antiviral activity for acyclovir loaded nano-niosomes of about 3 times in comparison with free drug. Conclusion: The results of this study revealed ACV-N have a higher antiviral activity compared with free drug; it could be a suitable carrier for delivery of acyclovir in the treatment of HSV-1 infections.

Item Type: Article
Additional Information: cited By 2
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/30

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