Pharmacokinetics of calycopterin and xanthmicrol, two polymethoxylated hydroxyflavones with anti-angiogenic activities from Dracocephalum kotschyi Bioss

Zamani, S.-S. and Hossieni, M. and Etebari, M. and Salehian, P. and Ebrahimi, S.A. (2016) Pharmacokinetics of calycopterin and xanthmicrol, two polymethoxylated hydroxyflavones with anti-angiogenic activities from Dracocephalum kotschyi Bioss. DARU, Journal of Pharmaceutical Sciences, 24 (1). pp. 1-10.

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Pharmacokinetics-of-calycopterin-and-xanthmicrol-two-polymethoxylated-hydroxyflavones-with-antiangiogenic-activities-from-Dracocephalum-kotschyi-Bioss2016DARU-Journal-of-Pharmaceutical-SciencesOpen-Access.pdf

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Abstract

Background: Recently flavonoids have attracted the attention of researchers in the fight against cancer. Calycopterin and xanthomicrol, are two polymethoxylated flavonoids found in the aerial parts of Dracocephalum kotschyi Bioss.. We have recently shown that these compounds possess antiangiogenic activity and may be of value as potential anticancer agents. In order to demonstrate putative in vivo antitumor effect of these compounds we needed preliminary information on both pharmacokinetics and toxicological properties of these two agents. Method: A new online SPE HPLC method for measurement of calycopterin and xanthomicrol in rat plasma was developed. Pharmacokinetic parameters of calycopterin and xanthomicrol, after i.v. administration in rats, were determined. Results: The plasma half-life for both agents was around 4 h, however, the volume of distribution of calycopterin appeared to be about 8 times greater than xanthomicrol. This was probably due the greater hydrophobicity of the former which had other consequences such as much smaller maximum plasma concentration of calycopterin compared to its less methoxylated congener. Preliminary toxicological study of xanthomicrol failed to show any behavioral, histological and biochemical adverse effects after repeated administrations of high doses. Graphical Abstract: Pharmacokinetics of xanthomicrol in rats. © 2016 The Author(s).

Item Type: Article
Additional Information: cited By 0
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 08 Jul 2018 03:20
Last Modified: 12 Oct 2019 06:09
URI: http://eprints.iums.ac.ir/id/eprint/3149

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