Protective Effect of Ocimum basilicum Essential Oil Against Acetic Acid�Induced Colitis in Rats

Rashidian, A. and Roohi, P. and Mehrzadi, S. and Ghannadi, A.R. and Minaiyan, M. (2016) Protective Effect of Ocimum basilicum Essential Oil Against Acetic Acid�Induced Colitis in Rats. Journal of Evidence-Based Complementary and Alternative Medicine, 21 (4). NP36-NP42.

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Abstract

Ocimum basilicum L has been traditionally used for the treatment of inflammatory bowel disease in Iran. This study investigates the ameliorative effect of Ocimum basilicum essential oil on an acetic acid�induced colitis model in rats. Ocimum basilicum essential oil with 2 doses (200 and 400 μL/kg) significantly ameliorated wet weight/length ratio of colonic tissue compared to the control group. Higher doses of essential oil (200 and 400 μL/kg) significantly reduced ulcer severity, ulcer area, and ulcer index. On the other hand, histological examination revealed the diminution of total colitis index as a marker for inflammatory cell infiltration in the colonic segments of rats treated with Ocimum basilicum essential oil (200 and 400 μL/kg). The increased level of myeloperoxidase was significantly decreased after the treatment with the essential oil (200 and 400 μL/kg). These results suggest that Ocimum basilicum exhibits protective effect against acetic acid�induced colitis. © 2015, © The Author(s) 2015.

Item Type: Article
Additional Information: cited By 3
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 08 Jul 2018 03:07
Last Modified: 09 Oct 2019 05:45
URI: http://eprints.iums.ac.ir/id/eprint/3204

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