Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population

Madadi, F. and Khaniani, M.S. and Shandiz, E.E. and Ayromlou, H. and Najmi, S. and Emamalizadeh, B. and Taghavi, S. and Jamshidi, J. and Tafakhori, A. and Shahidi, G.-A. and Darvish, H. (2016) Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population. Genetic Testing and Molecular Biomarkers, 20 (10). pp. 629-632.

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Abstract

Aims: Parkinson's disease (PD) is one of the most common neurodegenerative disorders; its etiology includes both genetic and environmental factors and their interactions. The ZNF512B, SLC41A1, and ALDH2 genes have recently been identified as contributing to PD. In this study we investigated the association of alleles of these genes with PD in the Iranian population. Methods: In a case-control study, rs2275294, rs11240569, and rs4767944, three single nucleotide polymorphisms in ZNF512B, SLC41A1, and ALDH2 genes, respectively, were genotyped in 490 PD patients and 490 controls. The genotype and allele frequencies were compared between the two groups using chi-square and logistic regression tests. Results: A significant association between the rs11240569 polymorphism and a reduced risk of PD was found (p = 0.014, OR = 0.76, 95 CI: 0.60-0.94 for allele frequencies). We did not find any associations between PD and the rs2275294 and rs4767944 polymorphisms. Conclusion: The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of PD was replicated in our population. � Copyright 2016, Mary Ann Liebert, Inc.

Item Type: Article
Additional Information: cited By 2
Depositing User: eprints admin
Date Deposited: 08 Jul 2018 03:00
Last Modified: 08 Jul 2018 03:00
URI: http://eprints.iums.ac.ir/id/eprint/3230

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