The predictors of no-reflow phenomenon after primary angioplasty for acute myocardial infarction

Aeinfar, K. and Firouzi, A. and Shahsavari, H. and Sanati, H. and Kiani, R. and Shakerian, F. and Mehr, A.Z. (2016) The predictors of no-reflow phenomenon after primary angioplasty for acute myocardial infarction. International Cardiovascular Research Journal, 10 (3). pp. 107-112.

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Background: No-reflow phenomenon is a serious complication of primary Percutaneous Coronary Intervention (PCI), which may increase the risk of progressive myocardial damage, profound left ventricular dysfunction, and death. Objectives: This study aimed to investigate the incidence of no-reflow phenomenon and its clinical, para-clinical, and angiographic determinants in patients who underwent primary PCI for ST Elevation Myocardial Infarction (STEMI). Patients and Methods: This non-randomized prospective cohort study was conducted on 397 patients in a cardiovascular tertiary care center in Tehran, Iran from April 2012 to April 2014. The inclusion criteria of the study were presenting with acute STEMI of � 12 h duration or having admitted between 12 and 24 hours after onset with symptoms and signs of ongoing ischemia. The participants underwent standard coronary angiography. No-reflow phenomenon was defined as a Thrombolysis In Myocardial Infarction (TIMI) flow � 2 and no presence of spasm, distal embolization, or dissection after completion of the procedure. The association between no-reflow and its determinants was assessed by chi-square, student�s t-test, or Mann�Whitney U test. Logistic regression models were also used for multivariate analysis. P values < 0.05 were considered to be statistically significant. Results: The participants� mean (SD) age was of 59 (12.2) years and female/male ratio was 83/314. The incidence of no-reflow phenomenon was 63 (15.9). Besides, the results of multivariate analysis showed that only thrombus burden, lesion length, time to reperfusion, and type of occlusion had an adjusted association with this phenomenon. Conclusions: The study results suggested that no-reflow phenomenon after primary PCI would be predictable. Thus, preventive measures, such as using distal protective devices or administration of platelet glycoprotein IIb/IIIa antagonists, are advised to be used in high-risk patients. © 2016, Iranian Cardiovascular Research Journal. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Subjects: WG Cardiovascular System
Depositing User: eprints admin
Date Deposited: 08 Jul 2018 02:31
Last Modified: 13 Oct 2019 10:27

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