Protein-protein interaction network of celiac disease

Azodi, M.Z. and Peyvandi, H. and Rostami-Nejad, M. and Safaei, A. and Rostami, K. and Vafaee, R. and Heidari, M. and Hosseini, M. and Zali, M.R. (2016) Protein-protein interaction network of celiac disease. Gastroenterology and Hepatology from Bed to Bench, 9 (4). pp. 268-277.

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Abstract

The aim of this study is to investigate the Protein-Protein Interaction Network of Celiac Disease. Background: Celiac disease (CD) is an autoimmune disease with susceptibility of individuals to gluten of wheat, rye and barley. Understanding the molecular mechanisms and involved pathway may lead to the development of drug target discovery. The protein interaction network is one of the supportive fields to discover the pathogenesis biomarkers for celiac disease. Material and methods: In the present study, we collected the articles that focused on the proteomic data in celiac disease. According to the gene expression investigations of these articles, 31 candidate proteins were selected for this study. The networks of related differentially expressed protein were explored using Cytoscape 3.3 and the PPI analysis methods such as MCODE and ClueGO. Results: According to the network analysis Ubiquitin C, Heat shock protein 90kDa alpha (cytosolic and Grp94); class A, B and 1 member, Heat shock 70kDa protein, and protein 5 (glucose-regulated protein, 78kDa), T-complex, Chaperon in containing TCP1; subunit 7 (beta) and subunit 4 (delta) and subunit 2 (beta), have been introduced as hub-bottlnecks proteins. HSP90AA1, MKKS, EZR, HSPA14, APOB and CAD have been determined as seed proteins. Conclusion: Chaperons have a bold presentation in curtail area in network therefore these key proteins beside the other hubbottlneck proteins may be a suitable candidates biomarker panel for diagnosis, prognosis and treatment processes in celiac disease. � 2016 RIGLD, Research Institute for Gastroenterology and Liver Diseases.

Item Type: Article
Additional Information: cited By 10
Depositing User: eprints admin
Date Deposited: 07 Jul 2018 08:49
Last Modified: 07 Jul 2018 08:49
URI: http://eprints.iums.ac.ir/id/eprint/3317

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