Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?

Mahshidfar, B. and Sameti, A. and Abbasi, S. and Farsi, D. and Mofidi, M. and Hafezimoghadam, P. and Rahimzadeh, P. and Rezai, M. (2016) Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients? Indian Journal of Critical Care Medicine, 20 (8). pp. 465-468.

[img] Text
Can-intravenous-acetaminophen-reduce-the-needs-to-more-opioids-to-control-pain-in-intubated-patients2016Indian-Journal-of-Critical-Care-MedicineOpen-Access.pdf

Download (546kB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Aims: To evaluate the effect of intravenous (IV) acetaminophen on reducing the need for morphine sulfate in intubated patients admitted to the Intensive Care Unit (ICU). Settings and Design: Current study was done as a clinical trial on the patients supported by mechanical ventilator. Subjects and Methods: Behavioral pain scale (BPS) scoring system was used to measure pain in the patients. All of the patients received 1 g, IV acetaminophen, every 6 h during the 1 st and 3 rd days of admission and placebo during the 2 nd and 4 th days. Total dose of morphine sulfate needed, its complications, and the BPS scores at the end of every 6 h interval were compared. Results: Totally forty patients were enrolled. The mean pain scores were significantly lower in the 2 nd and 4 th days (4.33 and 3.66, respectively; mean: 4.0) in which the patients had received just morphine sulfate compared to the 1 st and 3 rd days (7.36 and 3.93, respectively; mean: 5.65) in which the patients had received acetaminophen in addition to morphine sulfate too (P < 0.001). Cumulative dose of morphine sulfate used, was significantly higher in the 1 st and 3 rd days (8.92 and 3.15 mg, respectively; 12.07 mg in total) compared to the 2 nd and 4 th days (6.47 mg and 3.22 mg, respectively; 9.7 mg in total) (P = 0.035). Conclusion: In our study, IV acetaminophen had no effect on decreasing the BPSs and need of morphine sulfate in intubated patients admitted to ICU. © 2016 Indian Journal of Critical Care Medicine.

Item Type: Article
Additional Information: cited By 0
Subjects: WM Psychiatry
QX Parasitology
Depositing User: eprints admin
Date Deposited: 07 Jul 2018 08:37
Last Modified: 15 Oct 2019 06:07
URI: http://eprints.iums.ac.ir/id/eprint/3403

Actions (login required)

View Item View Item