Effect of Royal Jelly Intake on Serum Glucose, Apolipoprotein A-I (ApoA-I), Apolipoprotein B (ApoB) and ApoB/ApoA-I Ratios in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial Study

Khoshpey, B. and Djazayeri, S. and Amiri, F. and Malek, M. and Hosseini, A.F. and Hosseini, S. and Shidfar, S. and Shidfar, F. (2016) Effect of Royal Jelly Intake on Serum Glucose, Apolipoprotein A-I (ApoA-I), Apolipoprotein B (ApoB) and ApoB/ApoA-I Ratios in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial Study. Canadian Journal of Diabetes, 40 (4). pp. 324-328.

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Abstract

Objectives Type 2 diabetes is the most common metabolic disorder worldwide. Evidence supports a role for royal jelly (RJ) in reduction of serum glucose and lipids in animals and healthy subjects. The purpose of this study was to determine the effect of RJ intake on serum glucose, apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB) and ApoB/ApoA-I ratios in patients with type 2 diabetes. Methods Fifty patients with type 2 diabetes participated in a double-blind, placebo-controlled study. The participants were randomly divided into RJ and placebo groups and were given doses of 1000�mg royal jelly or placebo 3 times a day for 8 weeks, respectively. Weight, height, fasting blood glucose, ApoA-I and ApoB were measured at baseline and endpoint. Results There were no significant differences in baseline characteristics and dietary intakes between groups. The mean difference in glucose concentrations decreased in the RJ group (�9.4�mg/dL vs. 4�mg/dL; p=0.011). The mean difference in ApoA-I concentrations increased in the RJ group (34.4�mg/dL vs. �1.08�mg/dL; p=0.013). There was a significant decrease in mean difference of ApoB/ApoA-I in the RJ group compared with the placebo group (0.008 vs. 0.13; p<0.044), respectively. Conclusions These data suggest that RJ intake may have desirable effects on serum glucose, Apo-A-I concentrations and ApoB/ApoA-I ratios in people with type 2 diabetes. © 2016 Canadian Diabetes Association

Item Type: Article
Additional Information: cited By 4
Depositing User: eprints admin
Date Deposited: 07 Jul 2018 03:51
Last Modified: 07 Jul 2018 03:51
URI: http://eprints.iums.ac.ir/id/eprint/3444

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