Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population

Firouzabadi, N. and Shafiei, M. and Bahramali, E. and Ebrahimi, S.A. and Bakhshandeh, H. and Tajik, N. (2012) Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population. Psychiatry Research, 200 (2-3). pp. 336-342.

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Abstract

Genetic factors contribute substantially to the likelihood of developing major depressive disorder (MDD). The importance of renin-angiotensin system (RAS) elements in cognition and behaviour and their involvement in aetiology and treatment of depression imply that RAS gene polymorphism(s) associated with RAS overactivity might also be associated with depression. In the present study, genotype and allele frequencies of six common polymorphisms of genes encoding for RAS components were determined in DNAs extracted from venous blood of 191 depressed and 104 healthy individuals using polymerase chain reaction (PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and serum angiotensin-converting enzyme (ACE) activity was assayed using a high-performance liquid chromatography (HPLC) method. The results showed, for the first time, that GG genotype of ACE A2350G was significantly associated with MDD among Iranian participants (P=0.001; odds ratio (OR)=6.2; 95 confidence interval (CI)=2.1-18.3). Significant higher serum ACE activity (P=0.0001) as well as higher diastolic blood pressure (P=0.036) were observed in depressed patients compared to the healthy control group. Depressed patients carrying GG genotype of the A2350G polymorphism had a significantly higher serum ACE activity (P=0.02) than individuals with either AA or AG genotype. In conclusion, this study supports the hypothesis of RAS overactivity in depression in that the genotype associated with higher serum ACE activity in an Iranian population was also associated with MDD. © 2012 Elsevier Ireland Ltd.

Item Type: Article
Additional Information: cited By 11
Uncontrolled Keywords: dipeptidyl carboxypeptidase; DNA, adult; aged; angiotensin converting enzyme gene; article; blood sampling; controlled study; diastolic blood pressure; disease association; enzyme activity; enzyme assay; enzyme blood level; female; gene; gene frequency; genotyping technique; high performance liquid chromatography; human; Iran; major clinical study; major depression; male; outcome assessment; polymerase chain reaction; priority journal; renin angiotensin aldosterone system; restriction fragment length polymorphism; single nucleotide polymorphism, Adult; Aged; Alleles; Case-Control Studies; Depressive Disorder, Major; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Iran; Male; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Single Nucleotide; Renin-Angiotensin System
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/36

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