Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression

Firouzabadi, N. and Tajik, N. and Bahramali, E. and Bakhshandeh, H. and Ebrahimi, S.A. and Maadani, M. and Rasoulian, M. and Mobasheri, T. and Shafiei, M. (2012) Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression. Clinical Biochemistry, 45 (16-17). pp. 1347-1352.

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Objectives: Major depressive disorder (MDD) is an increasingly recognized risk factor of coronary artery disease (CAD). The aim of this study was to assess the relationship between renin-angiotensin system (RAS) genetic polymorphisms and CAD in a sample of depressed Iranian patients. Design and methods: A total of 191 patients with a history of unipolar depression were enrolled in a case/control study. The presence of MDD was reconfirmed at study entry using DSM-IV criteria and CAD was diagnosed by coronary angiography. Genotyping of six RAS genes polymorphisms was performed by a modified PCR-RFLP method. Results: DD genotype of ACE I/D was independently associated with the incidence of CAD in depressed patients (P= 0.011, OR = 9.41, 95 CI: 1.68-17.81). Moreover, serum creatinine (P= 0.033, OR = 11.91, 95CI: 7.23-15.62) was an independent predictor of CAD among depressed individuals. Conclusion: ACE I/D polymorphism may play a major role in the development of CAD amongst Iranian depressed patients. © 2012 The Canadian Society of Clinical Chemists.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: dipeptidyl carboxypeptidase, adult; angiocardiography; article; controlled study; coronary artery disease; disease association; DSM-IV; female; genetic polymorphism; genotype; human; Iran; major clinical study; major depression; male; polymerase chain reaction; priority journal; renin angiotensin aldosterone system; restriction fragment length polymorphism, Aged; Amplified Fragment Length Polymorphism Analysis; Case-Control Studies; Coronary Artery Disease; Depressive Disorder; Female; Gene Frequency; Genetic Association Studies; Humans; Iran; Male; Middle Aged; Multivariate Analysis; Peptidyl-Dipeptidase A; Polymorphism, Single Nucleotide; Renin-Angiotensin System; Risk Factors; Sequence Analysis, DNA
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Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13

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