Sensitivity or resistance to steroid therapy in children with idiopathic nephrotic syndrome is not associated with polymorphism of angiotensin converting enzyme (ACE)

Ahmadi, P. and Hoseini, R. and Rahimi-Moghaddam, P. and Yasin Ahmadi, S.A. (2016) Sensitivity or resistance to steroid therapy in children with idiopathic nephrotic syndrome is not associated with polymorphism of angiotensin converting enzyme (ACE). Journal of Applied Pharmaceutical Science, 6 (12). pp. 206-208.

[img] Text
Sensitivity-or-resistance-to-steroid-therapy-in-children-with-idiopathic-nephrotic-syndrome-is-not-associated-with-polymorphism-of-angiotensin-converting-enzyme-ACE2016Journal-of-Applied-Pharmaceutical-ScienceOpen.pdf

Download (312kB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

It's about years that the relation between renin angiotensin aldosterone system (RAS) and involving enzymes such as angiotensin converting enzyme (ACE) with nephrotic syndrome is under the focus of researchers and also there are a lot of meta-analyses. However there were few studies investigated the relation of ACE polymorphism and sensitivity or resistance to steroid therapy in children. So we intend to do that. In the current study the sample size was 40 children. Among them, 22 patients were sensitive and 18 patients were resistant to steroid therapy. The samples were collected from Ali-Asghar pediatric hospital in Tehran, Iran. We used polymerase chain reaction (PCR) for the genotyping. After that, we used Chi-squared test for statistical analysis. The statistical analysis showed no significant correlation between ACE polymorphism and sensitivity or resistance to steroid therapy (P = 0.77). Although the frequency of DD genotype was higher in the resistant group, but this difference was not statistically significant. Finally we found that although based on previous studies, D allele and DD genotype are more frequent in children with idiopathic nephrotic syndrome in comparison to healthy children, but the resistance or sensitivity to steroid therapy in children is not associated with ACE polymorphism. Further meta-analysis on the studies done on children is suggested. � 2016 Parisadat Ahmadi et al.

Item Type: Article
Additional Information: cited By 1
Subjects: WJ Urogenital System
WS Pediatrics
Depositing User: eprints admin
Date Deposited: 04 Jul 2018 04:30
Last Modified: 09 Nov 2019 09:50
URI: http://eprints.iums.ac.ir/id/eprint/4110

Actions (login required)

View Item View Item