Protective effects of Lithium on Sumatriptan-induced memory impairment in mice

Nikoui, V. and Javadi-Paydar, M. and Salehi, M. and Behestani, S. and Dehpour, A.-R. (2016) Protective effects of Lithium on Sumatriptan-induced memory impairment in mice. Acta Medica Iranica, 54 (4). pp. 226-232.

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Abstract

Lithium is a drug used for the treatment of bipolar disorder. It has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-HT1B/1D serotonin receptors. Sumatriptan is a 5- HT1B/1D receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. In this study, effects of lithium on sumatriptan-induced memory impairment have been determined in a two trial recognition Y-maze and passive avoidance tests. Male mice weighing 25-30 g were divided into several groups randomly. In Y-maze test, effects of lithium (1,5,10,20,40,80 mg/kg) and sumatriptan (1,5,10 mg/kg) were assessed on memory acquisition, then lithium (0.1,1,10 mg/kg) and sumatriptan (1,10 mg/kg) were studied in passive avoidance test. Effects of lithium (1mg/kg) on sumatriptan (10 mg/kg)-induced memory impairment were studied in both of tests. The present study demonstrated that sumatriptan impaired memory in Y-maze and passive avoidance tests (P<0.05, P<0.01, respectively). Lithium did not show any significant effect on memory function compared to saline- treated control group in both tests (P>0.05), but significantly reversed sumatriptan-induced memory impairment in Y-maze and passive avoidance tests (P<0.001, P<0.05, respectively). It is concluded that lithium reverses the sumatriptan-induced memory impairment probably through 5-HT1B/1D receptors antagonism. © 2016 Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 02 Jul 2018 10:21
Last Modified: 10 Nov 2019 11:08
URI: http://eprints.iums.ac.ir/id/eprint/4162

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