Investigation of digoxin solubility in different cosolvent systems

Zakeri-Milani, P. and Ebrahimi, S. and Valizadeh, H. (2012) Investigation of digoxin solubility in different cosolvent systems. Pharmaceutical Sciences, 18 (2). pp. 87-92.

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Abstract

Objectives: Digoxin is a drug with very low aqueous solubility, low therapeutic dose and low therapeutic index. Soft gelatin capsule is an ideal dosage form to formulate low soluble drugs that provides faster dissolution, higher bioavailability and higher content uniformity. The purpose of the present study is to enhance digoxin solubility using appropriate vehicles to prepare digoxin soft gelatin capsule core formulation. Methods: Solubility of digoxin in different solvents, including water, ethanol, polyethylene glycol 400, propylene glycol, transcutol and binary and/or ternary solvent systems were investigated using shake-flask method. Saturated solutions of these solvents and solvent mixtures were shaken at 25°C for 48 h. After equlibrium, the supernatant layer was withdrawn and passed through 0.45 μm filter. Concentrations of drug in solutions were determined by HPLC and UV method. The mathematical mixture design was used to design the solvent systems. Results: The obtained results indicated that best co-solvent for increasing the solubility of digoxin is ethanol. Digoxin solubility in other co-solvents also was more than its aqueous solubility. Using co-solvency method, the solubility was increased up to 14.5 times more than its aqueous solubility. Conclusion: It is concluded that digoxin solubility could be increased using co-solvency method to achieve appropriate formulations for designing soft gelatin capsules.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: alcohol; digoxin; macrogol 400; propylene glycol; solvent; water, aqueous solution; article; drug formulation; drug solubility; high performance liquid chromatography; supernatant; ultraviolet radiation
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/42

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