Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial

Zamanian, F. and Jalili, M. and Moradi-Lakeh, M. and Kia, M. and Aghili, R. and Aghili, S.M. (2016) Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial. Pain Research and Treatment, 2016.

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Abstract

Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided into two groups (n=79) and received either 10 mg morphine or 100 mg indomethacin suppositories. The severity of pain was measured using verbal numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the administration of analgesics. Drug side effects as well as patients' vital signs were also recorded. Results. The mean decrease in the pain score during the first 20 minutes was significantly higher among those who received morphine suppository. However, no significant difference was observed between the two groups regarding the mean decrease in pain score during the first 40, 60, and 90 minutes after the admission. Prevalence of drug side effects or changes in the vital signs was not significantly different between the two groups. Conclusions. Morphine suppositories seem to be more efficient in achieving rapid pain relief comparing to indomethacin. © 2016 Forough Zamanian et al.

Item Type: Article
Additional Information: cited By 1
Subjects: WJ Urogenital System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 02 Jul 2018 10:14
Last Modified: 11 Nov 2019 09:55
URI: http://eprints.iums.ac.ir/id/eprint/4218

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