Does B-type natriuretic peptide level predict outcome after arterial switch operation ?

Totonchi, Z. and Ghorbanlou, M. and Kiaei, M.M. and Yousefzadeh, A. and Mohaghegh, M.R. (2016) Does B-type natriuretic peptide level predict outcome after arterial switch operation ? Biosciences Biotechnology Research Asia, 13 (1). pp. 389-393.

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Abstract

Evaluation the predictive value of perioperative Plasma B-type natriuretic peptide level in arterial switch operation. Plasma B-type natriuretic peptide level was measured before and and 24 hours after surgery in 29 patients with arterial switch operation. We evaluated 29 patients (22 male,76,7 female 24) with mean age 67.93±84.09 days (range 6 days to 14months).The mean of BNP level before surgery was 7989.96±9691.94 and increased after surgery to 22391.35±11898.67 and difference between two groups was significant (P=0.003).In linear regression test the BNP did not correlate with sex(r=0.33, P=0.085) and age(r=0.14,P=0.45). Furthermore, BNP did not correlate with duration of mechanical ventilation (r=0.132,P=0.53), ICU stay (r=0.137,P=0.52) and with lactate level (r=0.41,P=0.054)after operation. During the study 4 patients(13.8) died and the mean of BNP 24h after operation among them was 35000.00±00.00.using chai-square and fisher exact test the correlation between BNP and death was significant(P=0.001). We implied that BNP level increased 24 hours after arterial switch operation, moreover we denoted it correlated well with the death rate and an increase in B-type natriuretic peptide 24 hours after surgery predicts poor postoperative outcome. However it did not correlate with duration of mechanical ventilation, ICU stay and lactate level in this patients.

Item Type: Article
Additional Information: cited By 0
Subjects: WG Cardiovascular System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 02 Jul 2018 09:59
Last Modified: 12 Nov 2019 08:04
URI: http://eprints.iums.ac.ir/id/eprint/4287

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