The effect of serum vitamin D normalization in preventing recurrences of benign paroxysmal positional vertigo: A case-control study

Sheikhzadeh, M. and Lotfi, Y. and Mousavi, A. and Heidari, B. and Bakhshi, E. (2016) The effect of serum vitamin D normalization in preventing recurrences of benign paroxysmal positional vertigo: A case-control study. Caspian Journal of Internal Medicine, 7 (3). pp. 173-177.

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Abstract

Background: Benign paroxysmal positional vertigo (BPPV) is a condition with recurrent attacks in a significant proportion of patients. The present case- control study was conducted to assess the influence of serum vitamin D normalization on recurrent attacks of vitamin D deficient patients. Methods: Diagnosis of BPPV was made based on history and clinical examination and exclusion of other conditions. Serum 25-hydroxy vitamin D (25-OHD) was measured using ELISA method and a levels of < 20 ng/ml was considered a deficiency of vitamin D. Inclusion criteria were as follows: history of recurrent attacks and serum 25-OHD < 20.ng/ml. While the patients with history of trauma, surgery and chronic systemic diseases were excluded. The patients were classified into two groups: treatment and control, intermittently. Both groups received Epley rehabilitation therapy one session per week for 4 weeks but the treatment group received an additional supplement of 50.000 IU of vitamin D (cholecalciferol) weekly for two months to achieve serum 25-OHD � 30 ng/ml and the study patients were followed-up for 6 months. Results: Twenty-seven patients were allocated to each group. At baseline, serum 25-OHD was similar (10.7�2.3 vs 11.41�1.9, P=0.23). At month 2, serum 25-OHD in the treatment group increased significantly to � 30 ng/ml, whereas serum 25-OHD in the control group remained unchanged (34.2�3.3 vs 10.6 10.6�2.2 ng/ml, P=0.001). During the follow-up period, attacks of BPPV in the treatment group decreased significantly compared with the control group (14.8 vs 96.3 OR= 0.18, P=0.001). Conclusion: The findings of this study indicate that the normalization of serum vitamin D significantly reduces BPPV recurrences.

Item Type: Article
Additional Information: cited By 4
Subjects: WL Nervous System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 02 Jul 2018 09:55
Last Modified: 13 Nov 2019 05:22
URI: http://eprints.iums.ac.ir/id/eprint/4308

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