Drug utilization and evaluation of prophylactic antibiotics in CABG patients

Farsad, B.F. and Bakhshandeh, H. and Mahboubi, S.T. (2016) Drug utilization and evaluation of prophylactic antibiotics in CABG patients. Biomedical and Pharmacology Journal, 9 (2). pp. 563-572.

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Prophylactic intravenous antibiotics should be routinely administrated to patients undergoing cardiac surgery. After cardiac surgery the patients are routinely administrated with prophylactic intravenous antibiotics. The duration and doses of such antibiotics are still controversial and the wide spectrum of prophylactic antibiotics used across the planet. It is important to bear in mind the sensitivity of administrating post-surgical antibiotics, using guidelines for standard administration prescribing are either missing or not effectively treated in many countries. However antibiotic prophylaxis is not the only preventative measures. The most common antibiotics used in the management of CABG associated infections different antibiotics been investigated. Different generation of Cephalospurins are most important study groups of antibiotics. It is important to appreciate that this reduction is not refer as a primary goal for surgical prophylaxis. To compare the antibiotics prophylaxis utilization in Shahid Rajaei Heart Center, Tehran, Iran, with international recognized standards, we conducted an observational 6-month study at this center, by a sectional, descriptive and prospective study.This review including the antibiotics administrated to the patients during their hospitalization in ICU as well as CCU in Shahid Rajaei hospital. The data gathered was done on the bases of a questionnaire including the patients' history and the administrated antibiotics.. Each case is independently compared with the respective guideline in order to study its consistency (in dose, duration and frequency) to globally-applied guideline, i.e. ASHP, ACC/AHA, NHS ESC etc. The collected data have been analyzed by SPSS software, in order to figure out the descriptive report. As the background characteristics, 130 patients (37 women, 93 men) with mean age of 64±8 years participated. Most of the Antibiotics prescriptions did not follow the guidelines in proper manner. The most prevalent Antibiotics utilized is this center for reduction of SSI after CABG, are Vancomycin, Ceftriaxone, Cefazolin and Ciprofloxacin. The most prominent problem in Antibiotics prophylaxis utilization in the target medical center is the non-compliance of selection and duration of antibiotics to the applicable guidelines. © 2016, Oriental Scientific Publishing Company. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Subjects: WA Public Health
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 02 Jul 2018 09:52
Last Modified: 13 Nov 2019 06:17
URI: http://eprints.iums.ac.ir/id/eprint/4332

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