Morphine/codeine ratio, a key in investigating a case of doping

Seif-Barghi, T. and Moghadam, N. and Kobarfard, F. (2015) Morphine/codeine ratio, a key in investigating a case of doping. Asian Journal of Sports Medicine, 6 (4).

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Abstract

Introduction: Consumption of codeine can lead to positive urine test for morphine in athletes. Morphine is classified as a prohibited doping drug while Codeine is not. Morphine/codeine ratio is used in forensic medicine to distinguish the consumption of codeine from abuse of morphine and other narcotics. Case Presentation: We present an athlete with positive urine test for morphine with a history of consumption of codeine. The disciplinary committee came to conclusion that the athlete had not consumed morphine and did not violate doping code based on morphine/codeine ratio. Conclusions: Analysis of codeine to morphine metabolism rate is needed when we are using morphine/codeine ratio to rule out abuse of narcotics. WADA should consider analysis for the CYP2D6 alleles (main metabolizer of codeine) in case of including morphine/codeine ratio in future prohibited list. The possibility of ultra-rapid CYP2D6 cannot be ruled out in certain results of morphine/codeine near the cut point. © 2015, Sports Medicine Research Center.

Item Type: Article
Additional Information: cited By 5
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 02 Jul 2018 08:46
Last Modified: 25 Nov 2019 11:29
URI: http://eprints.iums.ac.ir/id/eprint/4598

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