Effect of crocus sativus on gentamicin induced nephrotoxicity

Ajami, M. and Eghtesadi, S. and Pazoki-Toroudi, H. and Habibey, R. and Ebrahimi, S.A. (2010) Effect of crocus sativus on gentamicin induced nephrotoxicity. Biological Research, 43 (1). pp. 83-90.

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Abstract

Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 days and gentamicin 80 mg/kg/d for five days, starting from day 6. At the end of treatment, blood samples were taken for measurement of serum creatinine (SCr) and BUN. The left kidney was prepared for histological evaluation and the right kidney for Malondialdehyde (MDA) measurement. Gentamicin 80 (mg/k/d) increased SCr, BUN and renal tissue levels of MDA and induced severe histological changes. Saffron at 40 mg/k/d significantly reduced gentamicin-induced increases in BUN and histological scores (p<0.05). Gentamicin-induced increases in BUN, SCr and MDA and histological injury were significantly reduced by treatment with saffron 80 mg/k/d (p<0.05, p<0.001, p<0.05, and p<0.001 respectively). In conclusion, our results suggest that saffron treatment reduces gentamicin induced nephrotoxicity and this effect seems to be dose dependent.

Item Type: Article
Additional Information: cited By 25
Uncontrolled Keywords: antiinfective agent; gentamicin; malonaldehyde; plant extract, animal; article; chemically induced disorder; chemistry; Crocus; hospitalization; kidney disease; male; rat; Wistar rat, Animals; Anti-Bacterial Agents; Crocus; Gentamicins; Kidney Diseases; Male; Malondialdehyde; Plant Extracts; Rats; Rats, Wistar; Severity of Illness Index, Crocus; Crocus sativus; Rattus; Rattus norvegicus
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/47

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