An image processing technique for diagnosis of Alzheimer's disease

Mahmoudian, M. and Ebrahimi, S.A. and Kiani, Z. (2009) An image processing technique for diagnosis of Alzheimer's disease. Journal of Research in Medical Sciences, 14 (4). pp. 205-209.

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Abstract

BACKGROUND: Patients with Alzheimer's disease (AD) reportedly exhibit hypersensitivity to much diluted tropicamide solution (0.005), a M4 muscarinic receptor antagonist. Therefore intraocular application of 0.005 tropicamide may be useful for screening dementia. The aim of this study was to simplify the pupil response test by using a new image analyzing system, which consists of a cheap, simple, and easy to use web-camera and a computer. METHODS: Intraocular tropicamide of 0.005 concentration was administered in 3 groups: Alzheimer's disease patients (n = 8, average age = 76 ± 5), non-Alzheimer's disease elderly (n = 6, average age = 65 ± 7), and young subjects (n = 8, average age = 28 ± 5). Every 5 minutes for 60 minutes, image of the eye's shape were taken, and the diameter of the pupils was measured. RESULTS: The results showed that differences in pupil dilation rate between Alzheimer's disease and non-Alzheimer's disease subjects were statistically significant. ROC analysis showed that after 35 minutes the sensitivity and specificity of the test were 100. CONCLUSIONS: Based on our results, we concluded that this recording system might be an appropriate and reliable tool for pupil response diagnosis test of Alzheimer's disease.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: sodium chloride; tropicamide, adult; aged; Alzheimer disease; article; clinical article; computer assisted diagnosis; controlled study; diagnostic imaging; digital imaging; false positive result; human; image processing; imaging system; pupil reflex; pupillography; pupillometry; sensitivity and specificity; videorecording
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/48

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