2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents

Emami, S. and Foroumadi, A. and Falahati, M. and Lotfali, E. and Rajabalian, S. and Ebrahimi, S.-A. and Farahyar, S. and Shafiee, A. (2008) 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. Bioorganic and Medicinal Chemistry Letters, 18 (1). pp. 141-146.

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Abstract

2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 μg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations. © 2007 Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: cited By 56
Uncontrolled Keywords: 2 hydroxyphenacyl 4 aminotriazolium derivative; 2 hydroxyphenacyl azole derivative; antifungal agent; fluconazole; miconazole; nitroblue tetrazolium; pyrrole derivative; unclassified drug, animal cell; antifungal activity; article; Aspergillus niger; Candida albicans; cell strain 3T3; colorimetry; drug cytotoxicity; drug structure; drug synthesis; Microsporum gypseum; minimum inhibitory concentration; mouse; nonhuman; reaction analysis; Saccharomyces cerevisiae; structure analysis, Acetophenones; Antifungal Agents; Azoles; Microbial Sensitivity Tests; Structure-Activity Relationship, Arthroderma gypseum; Aspergillus niger; Candida albicans; Fungi; Saccharomyces cerevisiae
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/51

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