Effects of mebudipine and dibudipine, two new calcium channel blockers on voltage-activated calcium currents of PC12 cells

Rouzrokh, A. and Ebrahimi, S.A. and Rahbr-Roshandel, N. and Mahmoudian, M. (2007) Effects of mebudipine and dibudipine, two new calcium channel blockers on voltage-activated calcium currents of PC12 cells. Acta Physiologica Hungarica, 94 (3). pp. 199-207.

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Abstract

Mebudipine and dibudipine are two newly synthesized dihydropyridine (DHP) calcium channel blockers that have been shown to have considerable relaxant effects on vascular and atrial smooth muscle. The in vitro half-lives of mebudipine and dibudipine are reported to be significantly longer than that of nifedipine. In this study, we investigated the effects of mebudipine and dibudipine on voltage-activated Ca2+ channels on differentiated PC12 cells and compared their potencies to amlodipine. Our results point to absence of voltage-activated Ca2+ currents in undifferentiated PC12 cells. It is also concluded that mebudipine and dibudipine, like amlodipine are L-type calcium channel blockers. When tested in a range of 10-100 μM, mebudipine is at least as potent as amlodipine in inhibition of peak Ba2+ currents in differentiated PC12 cells while dibudipine is significantly less potent compared to amlodipine and mebudipine. © 2007 Akadémiai Kiadó, Budapest.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: amlodipine; barium chloride; barium derivative; calcium channel blocking agent; calcium channel L type; chloride; dibudipine; drug derivative; mebudipine; nerve growth factor; nifedipine; unclassified drug, animal; article; cell differentiation; cell membrane potential; cell strain; comparative study; dose response; drug effect; metabolism; nerve cell; rat, Amlodipine; Animals; Barium Compounds; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Chlorides; Dose-Response Relationship, Drug; Membrane Potentials; Nerve Growth Factor; Neurons; Nifedipine; PC12 Cells; Rats
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/52

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