The decrease in NKG2D+ Natural Killer cells in peripheral blood of patients with metastatic colorectal cancer

Gharagozloo, M. and Kalantari, H. and Rezaei, A. and Maracy, M.R. and Salehi, M. and Bahador, A. and Hassannejad, N. and Narimani, M. and Sanei, M.H. and Bayat, B. and Ghazanfari, H. (2015) The decrease in NKG2D+ Natural Killer cells in peripheral blood of patients with metastatic colorectal cancer. Bratislava Medical Journal, 116 (5). pp. 296-301.

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Abstract

Background: Natural killer (NK) cells play important roles in the immune defense against tumors such as colorectal cancer. In humans, NKG2D is an activating immune receptor constitutively expressed in most cytotoxic lymphocytes including NK and CD8+ T cells. In this study, the expression of NKG2D molecule was investigated in peripheral blood NK cells from colorectal cancer patients and compared with healthy subjects. Methods: We studied 21 non-metastatic (low-grade), 17 non-metastatic (high-grade), 16 metastatic colorectal cancer patients, and 24 healthy controls. Peripheral blood samples were obtained to isolate peripheral blood mononuclear cells (PBMCs) and the percentage of peripheral blood NKG2D+CD3-CD56+ NK cells was analyzed by flow cytometry. The expression of NKG2D at mRNA level was also measured by real-time PCR in both, patients and control subjects. Results: The results showed a significant reduction in the percentage of NKG2D+NK cells as well as NKG2D mRNA expression in peripheral blood of metastatic colon cancer patients. Conclusion: This result suggests that decreased expression of activating NKG2D receptor in metastatic colorectal cancer might compromise NK cell function and allow tumor to evade immunity (Tab. 3, Fig. 4, Ref. 33). Text in PDF www.elis.sk.

Item Type: Article
Additional Information: cited By 3
Depositing User: eprints admin
Date Deposited: 01 Jul 2018 08:11
Last Modified: 01 Jul 2018 08:11
URI: http://eprints.iums.ac.ir/id/eprint/5347

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