Interaction of papaverine with the enalapril-induced cough in guinea pig

Ebrahimi, S.A. and Saghaeian-Shahri, T. and Shafiei, M. and Rostami, P. and Mahmoudian, M. (2006) Interaction of papaverine with the enalapril-induced cough in guinea pig. Acta Physiologica Hungarica, 93 (1). pp. 71-78.

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Background. Angiotensin Converting Enzyme Inhibitors (ACEIS) like enalapril are extremely effective in the treatment of hypertension and heart failure. One of the most important side-effects of these drugs which, can lead to cessation of therapy is a persistant dry cough, induced because of increased bradykinin levels in the lung. Although antitussive alkaloids like codeine are effective in suppressing this cough, they too present a wide range of side-effects, most notably addiction. Objective. In a previous work we were able to show that noscapine, a non-narcotic antitussive agent, was able to decrease enalapril induced cough in guinea pigs. In this work, papaverine, another non-narcotic alkaloid found in opium latex was tested in the guinea pig model for antitussive activity. Method. Cough was induced in enalapril pretreated guinea pigs by forcing the animals to inspire capsaicin aerosol in an air-tight chamber. Coughs were recorded in control animals and in those which had received different doses of papaverine. Characteristic changes in chamber air pressure, were detected by a pressure transducer. Results. At low doses (0.5 and 0.25 mg/kg) papaverine was able to decrease enalapril induced cough. Conclusion. This effect was not mediated by the action of the drug on μ receptors and was only observed in animals treated with enalapril. © 2006 Akadémiai Kiadó.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: dipeptidyl carboxypeptidase inhibitor; enalapril; papaverine; vasodilator agent, animal; article; coughing; guinea pig; male, Angiotensin-Converting Enzyme Inhibitors; Animals; Cough; Enalapril; Guinea Pigs; Male; Papaverine; Vasodilator Agents
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13

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