Allicin from garlic inhibits the biofilm formation and urease activity of Proteus mirabilis in vitro

Ranjbar-Omid, M. and Arzanlou, M. and Amani, M. and Shokri Al-Hashem, S.K. and Mozafari, N.A. and Doghaheh, H.P. (2015) Allicin from garlic inhibits the biofilm formation and urease activity of Proteus mirabilis in vitro. FEMS Microbiology Letters, 362 (9).

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Abstract

Several virulence factors contribute to the pathogenesis of Proteus mirabilis. This study determined the inhibitory effects of allicin on urease, hemolysin and biofilm of P. mirabilis ATCC 12453 and its antimicrobial activity against 20 clinical isolates of P. mirabilis. Allicin did not inhibit hemolysin, whereas it did inhibit relative urease activity in both pre-lysed (half-maximum inhibitory concentration, IC50 = 4.15 μg) and intact cells (IC50 = 21 μg) in a concentration-dependent manner. Allicin at sub-minimum inhibitory concentrations (2-32 μg mL-1) showed no significant effects on the growth of the bacteria (P>0.05), but it reduced biofilm development in a concentration-dependent manner (P<0.001).A higher concentration of allicin was needed to inhibit the established biofilms. Using the microdilution technique, the MIC90 and MBC90 values of allicin against P. mirabilis isolates were determined to be 128 and 512 μg mL-1, respectively.The results suggest that allicin could have clinical applications in controlling P. mirabilis infections. © FEMS 2015. All rights reserved.

Item Type: Article
Additional Information: cited By 8
Subjects: QW Microbiology. Immunology
Depositing User: eprints admin
Date Deposited: 01 Jul 2018 07:39
Last Modified: 13 Jan 2020 06:07
URI: http://eprints.iums.ac.ir/id/eprint/5483

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