Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent

Jahaniani, F. and Ebrahimi, S.A. and Rahbar-Roshandel, N. and Mahmoudian, M. (2005) Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry, 66 (13). pp. 1581-1592.

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Abstract

Spinal-Z, a methanolic mixture of dried powdered seeds of Peganum harmala Linn. and leaf of Dracocephalum kotschyii Boiss. is an Iranian ethno-medical remedy. It has been used for the treatment of various types of cancer for many years. To evaluate the use of Spinal-Z in treatment of cancer, we examined its effects against a panel of malignant cell lines and tumors induced in mice. The in vitro antiproliferative activities of Spinal-Z, the seed extract of P. harmala and the leaf extract of D. kotschyii were determined using the MTT assay. The concentration of the agent required to inhibit cell growth by 50 (IC50) was estimated. In addition, the anti-tumor activities of the remedy and its constituents were investigated. Viability of cells treated with Spinal-Z and its components decreased in a dose dependent manner. Spinal-Z and its components showed cytotoxic effects against all cell lines tested. The leaf extract of D. kotschyii showed a greater preferential cytotoxic effect than the seed extract of P. harmala and Spinal-Z, on all cell lines tested. Harmine showed cytotoxicity against HL60 and K562 cell lines. This could explain the cytotoxic effect of P. harmala on these cells. The leaf extract of D. kotschyii was able to inhibit tumor proliferation in mice. The active ingredient in the leaf extract of D. kotschyii appears to be a flavone identified as xanthomicrol. Xanthomicrol was able to inhibit proliferation of a number of malignant cells. The cytotoxic effects of xanthomicrol were more selective towards malignant cells than doxorubicin. © 2005 Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: cited By 72
Uncontrolled Keywords: antineoplastic agent; doxorubicin; flavone derivative; harmine; plant extract; xanthomicrol, angiosperm; animal; article; cell strain HL 60; cell survival; chemistry; drug effect; human; isolation and purification; mouse; plant; plant leaf; plant seed; tumor cell line, Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Doxorubicin; Flavones; Harmine; HL-60 Cells; Humans; Lamiaceae; Mice; Plant Extracts; Plant Leaves; Plants, Toxic; Seeds, Dracocephalum kotschyii; Peganum harmala
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/57

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