Evolution of hepatitis B virus surface gene and protein among Iranian chronic carriers from different provinces

Ramezani, F. and Alavian, S.M. and Sadeghi, A. and Khedive, A. and Ghalichi, L. and Norouzi, M. and Karimzadeh, H. and Malekzadeh, R. and Montazeri, G. and Nejatizadeh, A. and Ziaee, M. and Abedi, F. and Ataei, B. and Yaran, M. and Sayad, B. and Somi, M.H. and Sarizadeh, G. and Sanei-Moghaddam, I. and Mansour-Ghanaei, F. and Rafatpanah, H. and Keyvani, H. and Kalantari, E. and Saberfiroozi, M. and Rezaee, R. and Daram, M. and Mahabadi, M. and Goodarzi, Z. and Poortahmasebi, V. and Geravand, B. and Khamseh, A. and Mahmoodi, M. and Jazayeri, S.M. (2015) Evolution of hepatitis B virus surface gene and protein among Iranian chronic carriers from different provinces. Iranian Journal of Microbiology, 7 (4). pp. 214-220.

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Background and Objectives: Iranian chronic HBV carrier�s population has shown a unique pattern of genotype D distribution all around the country. The aim of this study was to explore more details of evolutionary history of carriers based on structural surface proteins from different provinces. Materials and Methods: Sera obtained from 360 isolates from 12 Different regions of country were used for amplification and sequencing of surface proteins. A detailed mutational analysis was undertaken. Results: The total ratio for Missense/Silent nucleotide substitutions was 0.96. Sistan and Kermanshah showed the lowest rate of evolution between provinces (P = 0.055). On the other hand, Khorasan Razavi and Khoozestan contained the highest ratio (P = 0.055). The rest of regions were laid between these two extremes. Azarbayjan and Guilan showed the highest proportion of immune epitope distribution (91.3 and 96, respectively). Conversely, Sistan and Tehran harbored the least percentage (66.6 and 68.8, respectively). Kermanshah province contained only 5.2, whereas Isfahan had 54.5 of B cell epitope distribution. In terms of T helper epitopes, all provinces showed a somehow homogeneity: 22.58 (Fars) to 46.6 (Khuzestan). On the other hand, distribution of substitutions within the CTL epitopes showed a wide range of variation between 6.6 (Khuzestan) and 63 (Kermanshah). Conclusion: Further to low selection pressure found in Iranian population, the variations between different regions designate random genetic drift within the surface proteins. These finding would have some applications in terms of specific antiviral regimen, design of more efficient vaccine and public health issues. © 2015, Tehran University of Medical Science. All rights reserved.

Item Type: Article
Additional Information: cited By 3
Depositing User: eprints admin
Date Deposited: 01 Jul 2018 05:10
Last Modified: 01 Jul 2018 05:10
URI: http://eprints.iums.ac.ir/id/eprint/5805

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